Designing, Constructing & Screening Molecular Glue Libraries to Identify Potent & Selective Glues for Neurodegenerative Targets
Time: 10:30 am
day: Conference Day Two
Details:
- The strategic design of molecular glue libraries, including the structural and chemical considerations required for specific targeting of tau, amyloid-beta and alpha-synuclein to improve the quantities reaching the target site of the protein aggregates
- The use of computational tools and modelling to predict what the most effective glues within a library will be
- High-throughput screening and biochemical assays for the identification of potent and selective glues for drug development
