Programmable Modulators of Undruggable Targets via Generative Language Models
Time: 9:30 am
day: Conference Day Two
Details:
- Generative language models can design selective peptide binders to any target, including those that are disordered and lack binding pockets
- Peptide binders can be fused to E3 ubiquitin ligases or deubiquitinases, driving programmable target degradation of proteins such as GFAP and mHTT and stabilization of proteins, such as p53
- These peptide-enzyme fusions can be readily encapsulated as mRNA in LNPs or encoded into AAVs for therapeutic delivery
