Round Table Discussion: Approaches to degrade proteins with molecular glues, and their therapeutic role
Time: 3:45 pm
day: Conference Day Two
Details:
- Novel studies in degrading pathogenic proteins by recruiting them to E3 ubiquitin ligases via small molecules that remodel protein surfaces to induce non-endogenous E3–substrate interactions
- Functional genomics, structural, and computational studies to identify how a small molecule degrades a B-cell lymphoma target by polymerizing it
- Polymerization potential of other transcription factors and how it opens avenues to target “undruggable” proteins
