Round Table Discussion: Breaking Barriers: Designing Optimized Degrader Molecules for CNS Targets
Time: 11:00 am
day: Conference Day Two
Details:
Selection of Target Proteins:
- What criteria should be used to select target proteins for degradation in neurodegenerative diseases?
- How do we prioritize targets based on disease relevance and druggability?
Design and Optimization of Degrader Molecules:
- What are the key considerations in designing effective PROTACs (Proteolysis-Targeting Chimeras) and molecular glues?
- How can we optimize the linker length, E3 ligase ligands, and target-binding moieties to enhance degrader efficacy and selectivity?
Mechanistic Insights and Structure-Activity Relationships (SAR):
- How do the structural features of degraders influence their mechanism of action and degradation efficiency?
- What are the latest advancements in understanding the SAR of protein degraders?
