Robert Blake

Company: Genentech

Job title: Senior Principal Scientist, Biochemical & Cellular Pharmacology

Seminars:

Panel Discussion: Breaking Down the Pitfalls in Protein Degrader Assays & Brainstorming CNS-Specific Considerations 11:45 am

Streamlining PROTAC sample handling to foster standardized degrader assay development and analysis Evaluating PROTAC behavior as small molecules to understand mechanism of action Spotlighting additional PK and in vitro cost and time burdens in non-optimized assay conditionsRead more

day: Conference Day Two

Re-Evaluating Pharmacokinetic Profiles, Brain Penetration & Off-Target Effects of PROTAC-Like Compounds Targeting Tau 1:15 pm

Exploring pharmacokinetic profiles of CNS protein degraders Evaluating small molecule measurements of brain penetration against previously reported data Analyzing understanding of off target-effects misleading target engagementRead more

day: Conference Day Two