Pre-Conference Workshop Day

Tuesday | February 18

8:30 am MORNING REFRESHMENTS & CHECK IN

9:30 am
WORKSHOP A
INTRODUCTION TO CNS & BBB BIOLOGY TO  UNLOCK DEEPER UNDERSTANDING FOR AIDING  ADVANCEMENTS

Synopsis

Protein degradation experts have long been working on oncology targets however with the shift towards exploring CNS indications it is imperative that chemists and protein engineers understand the unique biology of the brain and the blood brain barrier

Join this workshop to:

  • Hear the latest research on the brain and blood brain barrier to gain insight into basic neurobiology
  • Understand the disease pathology of high value disease areas, including neurodegeneration and neuroinflammation to better understand your future CNS drug targets
  • Delve into the pathological protein misfolding and aggregation pathways for Alzheimer’s, Parkinson’s, ALS, Prion Disease and more to gain a more comprehensive picture of the proteins most commonly studied for drug development

9:30 am
WORKSHOP C
INTRODUCTION TO PROTEIN DEGRADER BIOLOGY TO ENHANCE INSIGHTS FOR GREATER CONTEXT & COLLABORATION

  • Pranam Chatterjee Assistant Professor of Biomedical Engineering & Co-Founder (UbiquitX), Duke University

Synopsis

Neuroscience experts have begun exploring the use of protein degradation as a drug development approach, requiring better understanding of the specialised mechanisms that can be utilised in combating CNS diseases

Join this workshop to:

  • Understand the latest research on protein synthesis and the folding and mis-folding of proteins to get to grips with the fundamentals of CNS disease origin
  • Gain knowledge of the prime protein degradation pathways to understand the mechanisms of action to utilise during drug development
  • Explore the variation in protein design and function to understand how molecular properties can be optimised for drug delivery and efficacy

12:30 pm NETWORKING LUNCH

1:30 pm
WORKSHOP B
APPROACHES FOR TACKLING NEURODEGENERATIVE DISEASE TO ASSESS DRUG IMPACTS FOR BETTER FUTURE DEVELOPMENT

  • Ram Krishnan Head of Neurodegenerative Disease Cluster, Sanofi

Synopsis

Reviewing the previous research and the current approaches is crucial to the development of novel methodologies and advancing drugs to clinic

Workshop highlights include:

  • Assessing the current treatments and therapies for CNS diseases to recognize where improvements can be made for better drug development
  • Understanding the difficulties in curing neurodegenerative diseases to rethink approaches and advance treatments for better patient outcome
  • Exploring the benefits of protein degradation, and its potential for CNS diseases as a different method of drug development to revolutionise treatments for Alzheimer’s, Parkinson’s, CLS and Prion Diseases

1:30 pm
WORKSHOP D
STRATEGIES OF SUCCESSFUL PROTEIN DEGRADATION FOR BETTER UNDERSTANDING AND FUTURE PROGRESSION

  • Mikolaj Slabicki Cancer Program Group Leader & Postdoctoral Research Fellow, The Broad Institute of MIT & Harvard

Synopsis

Examining studies of previously developed protein degraders is vital for advancing current and novel approaches by understanding the methods that have proven successful in order to advance drug development

Workshop highlights include:

  • Investigating studies on protein degraders to deepen the understanding of methodologies known to be successful for advancing more drugs to clinic
  • Exploring the molecular constituents and mechanisms utilized in the development of protein degraders to optimise drug design for enhanced degrader delivery
  • Explore the interdisciplinary process of discovering and formulating specific protein degraders for utlising biological mechanisms that are able to degrade mis-folded proteins in the brain

4:30 pm END OF PRE-CONFERENCE WORKSHOP DAY

Download the Full Event Guide for more information on:

  • 20+ Biotech & Pharma Speakers
  • 4 Interactive Deep-Dive Workshops
  • 6+ Hours of Networking
  • & Much More!

 

Targeted Protein Degradation for CNS Event Guide