Marija Usenovic

Company: Merck & Co

Job title: Associate Principal Scientist

Seminars:

Panel Discussion: Striving Beyond Proteasome Capacity: Debating the Different Strategies for Protein Degradation in CNS 11:30 am

Outlining the theoretical biological limitations of proteasome-mediated degradation – does this correlate with reported PROTAC capabilities? Understanding the potential of lysosome and autophagy-mediated degradation to target extracellular, aggregated CNS disease proteins Weighing up strategies of preventing new aggregates forming against degrader existing disease proteins – which is the best route to go?Read more

day: Conference Day One

Roundtable Discussion: Starting From Scratch: Investigating CNS Targets Without Binding Inhibition Knowledge to Identify Brain & Pathology-Specific Target Proteins 9:30 am

Tackling difficult to drug targets across CNS disease pathologies What are the clinically effective targets for CNS protein degraders? Outlining best practices to screen and develop ligands specifically targeting toxic CNS aggregatesRead more

day: Conference Day Two