Panel Discussion: Striving Beyond Proteasome Capacity: Debating the Different Strategies for Protein Degradation in CNS

Time: 11:30 am
day: Conference Day One


  • Outlining the theoretical biological limitations of proteasome-mediated degradation – does this correlate with reported PROTAC capabilities?
  • Understanding the potential of lysosome and autophagy-mediated degradation to target extracellular, aggregated CNS disease proteins
  • Weighing up strategies of preventing new aggregates forming against degrader existing disease proteins – which is the best route to go?